중심성 과립세포치성종양의 면역조직학적 특성
Immunohistochemical Characteristics of Central Granular Cell Odontogenic Tumor
권태건, 정재광, 박의균, 신홍인,
소속 상세정보
권태건 ( Kwon Tae-Geon ) - 경북대학교 치의학전문대학원 구강악안면외과학교실
정재광 ( Jung Jae-Kwang ) - 경북대학교 치의학전문대학원 구강내과학교실
박의균 ( Park Eui-Kyun ) - 경북대학교 치의학전문대학원 구강병리학교실
신홍인 ( Shin Hong-In ) - 경북대학교 치의학전문대학원 구강병리학교실
KMID : 0829220110350020101
Abstract
The central granular cell odontogenic tumor is a rare benign odontogenic neoplasm of uncertain hisotogenesis characterized by varying amounts of eosinophilic granular cells and apparently inactive odontogenic epithelium with variable presence of calcified tissue. We present a case of central granular cell odontogenic tumor involving the maxilla of 35-year-old man with immunohistochemical characterization of granular cells. In microscopic view, the granular cells densely packed in sheets and lobules with abundant eosinophilic, granular cytoplasm and eccentric round-to-ovoid nuclei revealed immunoreactivity for vimentin, α1-antitrysin and CD68, and NSE but not for cytokeratin and S-100 protein while the interspersed odontogenic epithelial cells were positive for cytokeratin only. Granular cells also revealed strong PAS staining. Numerous concentric structured round to ovoid calcified aggregates were also noted. The lesion was treated with excision without recurrence for 8 years. Our immuohistochemical staining findings also suggest that the granular cells of central granular cell odontogenic tumor are mesenchymal in origin with possible histiocytic differentiation.
키워드
Calcification; Granular cells; Immunohistochemistry; Odontogenic tumor
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